FRACGP | KFP | Haematology | Anaemia

11 mins by GP Core Content for RACGP KFP, CAAKT, AKT, OSCE, by Dr Thomas Perkins FRACGP, MBBS |

NB: Alpha thal vs beta that wasn't explained
Alpha Thal is deletion of 1+ of the 4 genes for alpha globin
1-2 genes lost = symptomless carrier
3 genes = harm H = mould to mod disease
4 genes = hydrops details

Beta thal is beta chains in decr quantity rather than large deletions
Two mutations is homozygous is thal major

Features of thalassemia
Bossing
Hypertrophic of maxillae
Prominent Malay eminences
Depression of nasal bridge
Lethargic kids
FTT
delayed puberty